Engineering Magnetic Nanomaterials for Efficient Nanowarming
Outcome/Accomplishment
The NSF-funded Engineering Research Center (NSF ERC) for Advanced Technologies for the Preservation of Biological Systems (NSF ATP-Bio) is co-led by the University of Minnesota (UMN) and Massachusetts General Hospital (MGH). A core partner is the University of California at Riverside (UCR). Interdisciplinary collaboration between two labs at UCR and UMN significantly advanced the use of magnetic nanoparticles for nanowarming tissues.
Impact/Benefits
The researchers developed a novel surface functionalization technique that enhanced the colloidal stability and biocompatibility of magnetic nanoparticles. The optimized nanoparticles enabled the first successful vitrification and later nanowarming of a 1.5 mm thick iliac artery. The techniques are scalable and eventually hold promise for application across entire organ systems.
Explanation/Background
The engineered magnetic nanoclusters exhibit a specific absorption rate (SAR) of heat over twice as high as that of commercial iron oxide nanoparticles. A magnetic nanorod-mediated nanowarming strategy was developed to regulate the heating rates at different stages of the nanowarming process. In stage 1, near cryogenic temperatures, the magnetic nanorods were prealigned to promote a 42% increase in the heating rate. In stage 2, near the melting point of cryoprotective agents, the alignment was disrupted to effectively mitigate the heating rate, preventing overheating and ensuring uniform temperature distribution.
Location
Minneapolis, Minnesotawebsite
Start Year
Biotechnology and Healthcare
Biotechnology and Healthcare
Lead Institution
Core Partners
Fact Sheet
Outcome/Accomplishment
The NSF-funded Engineering Research Center (NSF ERC) for Advanced Technologies for the Preservation of Biological Systems (NSF ATP-Bio) is co-led by the University of Minnesota (UMN) and Massachusetts General Hospital (MGH). A core partner is the University of California at Riverside (UCR). Interdisciplinary collaboration between two labs at UCR and UMN significantly advanced the use of magnetic nanoparticles for nanowarming tissues.
Location
Minneapolis, Minnesotawebsite
Start Year
Biotechnology and Healthcare
Biotechnology and Healthcare
Lead Institution
Core Partners
Fact Sheet
Impact/benefits
The researchers developed a novel surface functionalization technique that enhanced the colloidal stability and biocompatibility of magnetic nanoparticles. The optimized nanoparticles enabled the first successful vitrification and later nanowarming of a 1.5 mm thick iliac artery. The techniques are scalable and eventually hold promise for application across entire organ systems.
Explanation/Background
The engineered magnetic nanoclusters exhibit a specific absorption rate (SAR) of heat over twice as high as that of commercial iron oxide nanoparticles. A magnetic nanorod-mediated nanowarming strategy was developed to regulate the heating rates at different stages of the nanowarming process. In stage 1, near cryogenic temperatures, the magnetic nanorods were prealigned to promote a 42% increase in the heating rate. In stage 2, near the melting point of cryoprotective agents, the alignment was disrupted to effectively mitigate the heating rate, preventing overheating and ensuring uniform temperature distribution.