The vision of the Center is to Revolutionize Metallic Biomaterials (RMB) and the underlying sciences and technologies, leading to engineered systems that will interface with the human body to prolong and improve quality of life--coupled with the development of a vibrant, diverse workforce well-prepared for the multidisciplinary and global challenges and opportunities of the 21st century. The Center's major goal is to revolutionize metallic biomaterials and smart coatings with built-in responsive biosensory capabilities that can adapt to biological changes to create novel bio-functional engineered systems, including craniofacial and orthopedic applications, cardiovascular and thoracic devices, and responsive biosensors and neural applications. The promise of these systems lies in the fact that new kinds of implants can adapt to the human body and eventually dissolve when no longer needed, thereby eliminating multiple surgeries and reducing health care costs.